Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/12853

TitleMethacrylated gellan gum hydrogels for application in nucleus pulposus regeneration : in vitro and in vivo studies
Author(s)Silva-Correia, Joana
Gonçalves, Vera M.
Oliveira, Joaquim M.
Reis, R. M.
Reis, R. L.
Issue dateSep-2011
Abstract(s)Natural-based hydrogels have been attracting great deal of attention for tissue engineering of nucleus pulposus (NP). Gellan gum is an extracellular microbial polysaccharide from Sphingomonas elodea that forms a firm and transparent gel with interesting features for use as an in vitro 3D cell support, or as an in vivo injectable system. Recently, gellan gum-based hydrogels (ionic- and photocrosslinked methacrylated gellan gum) have been proposed as potential candidates for NP regeneration1. An important feature of these hydrogels will be their capacity to control blood vessel growth, since the NP is naturally avascular. Our aim was to investigate the biological performance of the developed hydrogels, in vitro. The angiogenic/anti-angiogenic potential of the GG-based hydrogels was also carried out in vivo, using an optimized adaptation of the chorioallantoic membrane (CAM) assay.
TypeConference paper
URIhttp://hdl.handle.net/1822/12853
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Resumos em livros de atas de conferências - indexados no ISI Web of Science

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