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TitleIn vivo study on the angiogenic potential of gellan gum-based hydrogels for application in nucleus pulposus regeneration
Author(s)Silva-Correia, Joana
Gonçalves, Vera M.
Oliveira, Joaquim M.
Reis, R. M.
Reis, R. L.
Issue date2011
PublisherWichtig Editore
JournalInternational Journal of Artificial Organs
Abstract(s)Tissue engineering of nucleus pulposus (NP) offers a promising alternative strategy to current ineffective clinical approaches for treating intervertebral disc degeneration. Gellan gum-based hydrogels (ionic- and photo-crosslinked methacrylated gellan gum) have been recently proposed as potential candidates for NP regeneration. An important feature of these hydrogels will be their capacity to control blood vessel growth, since the NP is naturally avascular. Our aim was to investigate in vivo the angiogenic/antiangiogenic potential of the developed hydrogels, using an optimized adaptation of the chorioallantoic membrane (CAM) assay.
AccessOpen access
Appears in Collections:3B’s - Resumos em livros de atas de conferências - indexados no ISI Web of Science

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