Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/12818

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dc.contributor.authorPuppi, D.-
dc.contributor.authorPiras, A. M.-
dc.contributor.authorChiellini, F.-
dc.contributor.authorChiellini, E.-
dc.contributor.authorMartins, Albino-
dc.contributor.authorLeonor, I. B.-
dc.contributor.authorNeves, N. M.-
dc.contributor.authorReis, R. L.-
dc.date.accessioned2011-07-14T14:27:51Z-
dc.date.available2011-07-14T14:27:51Z-
dc.date.issued2011-
dc.date.submitted2011-
dc.identifier.issn1932-7005por
dc.identifier.urihttp://hdl.handle.net/1822/12818-
dc.description.abstractThis research activity was aimed at the development of composite bioactive scaffolds made of biodegradable three-arm branched-star poly(ε-caprolactone) (∗PCL), hydroxyapatite nanoparticles (HNPs) and clodronate (CD), a bisphosphonate that has demonstrated efficacy in the treatment of various bone diseases and as an anti-inflammatory drug. During the experimental work, the processing conditions for the fabrication of fibrous meshes, by either electrospinning or wetspinning, were optimized. Stemming from a previous research activity on electrospinning of ∗PCL, ∗PCL/HNPs 3D meshes were developed, evaluating the influence of fabrication parameters on the fibres’ morphology. By exploiting the binding affinity of bisphosphonates for hydroxyapatite, a methodology was set up for obtaining a physical linkage between CD and HNPs, with the aim of having a dual bioactive system loaded into ∗PCL fibrous mats. Fibres loaded with either CD or CD–HNP particles were thus produced and analysed by scanning electron microscopy for their morphology and by energy dispersive X-ray spectroscopy for their elemental compositionpor
dc.description.sponsorshipThis work was done within the framework of the European Network of Excellence 'EXPERTISSUES', Project No. NMP3-CT-2004-500283. Professor Ramani Narayan of Michigan Biotechnology Institute and Dr Fabio Neggiani of Abiogen Pharma-Pisa are acknowledged for supplying *PCL and CD, respectively.por
dc.language.isoengpor
dc.publisherWileypor
dc.relationNMP3- CT-2004-500283 - EXPERTISSUESpor
dc.rightsopenAccesspor
dc.subjectelectrospinningpor
dc.subjectwet-spinningpor
dc.subjectstar polymerspor
dc.subjectbisphosphonatespor
dc.subjectscaffoldspor
dc.subjecttissue engineeringpor
dc.titleOptimized electro- and wet-spinning techniques for the production of polymeric fibrous scaffolds loaded with bisphosphonate and hydroxyapatitepor
dc.typearticle-
dc.peerreviewedyespor
dc.relation.publisherversionhttp://onlinelibrary.wiley.compor
sdum.publicationstatuspublishedpor
oaire.citationStartPage253por
oaire.citationEndPage263por
oaire.citationIssue4por
oaire.citationTitleJournal of Tissue Engineering and Regenerative Medicinepor
oaire.citationVolume5por
dc.identifier.doi10.1002/term.310por
dc.identifier.pmid20661867por
dc.subject.wosScience & Technologypor
sdum.journalJournal of Tissue Engineering and Regenerative Medicinepor
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