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|Title:||Optimized electro- and wet-spinning techniques for the production of polymeric fibrous scaffolds loaded with bisphosphonate and hydroxyapatite|
Piras, A. M.
Leonor, I. B.
Neves, N. M.
Reis, R. L.
|Journal:||Journal of Tissue Engineering and Regenerative Medicine|
|Abstract(s):||This research activity was aimed at the development of composite bioactive scaffolds made of biodegradable three-arm branched-star poly(ε-caprolactone) (∗PCL), hydroxyapatite nanoparticles (HNPs) and clodronate (CD), a bisphosphonate that has demonstrated efficacy in the treatment of various bone diseases and as an anti-inflammatory drug. During the experimental work, the processing conditions for the fabrication of fibrous meshes, by either electrospinning or wetspinning, were optimized. Stemming from a previous research activity on electrospinning of ∗PCL, ∗PCL/HNPs 3D meshes were developed, evaluating the influence of fabrication parameters on the fibres’ morphology. By exploiting the binding affinity of bisphosphonates for hydroxyapatite, a methodology was set up for obtaining a physical linkage between CD and HNPs, with the aim of having a dual bioactive system loaded into ∗PCL fibrous mats. Fibres loaded with either CD or CD–HNP particles were thus produced and analysed by scanning electron microscopy for their morphology and by energy dispersive X-ray spectroscopy for their elemental composition|
|Appears in Collections:||3B’s - Artigos em revistas/Papers in scientific journals|
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|DPuppi-J Tissue Engineering and Regenerative Medicine 2011.pdf||Documento principal||529,5 kB||Adobe PDF||View/Open|