Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/11762

TitleFluorescence properties of a potential antitumoral benzothieno[3,2-b]pyrrole in solution and lipid membranes
Author(s)Castanheira, Elisabete M. S.
Abreu, Ana S.
Queiroz, Maria João R. P.
Ferreira, Paula M. T.
Coutinho, Paulo J. G.
Nazareth, N.
Nascimento, Maria São José
KeywordsBenzothienopyrrole
Antitumour properties
Fluorescence
Lipid membranes
Issue dateAug-2009
PublisherElsevier
JournalJournal of Photochemistry and Photobiology A: Chemistry
Citation"Journal of Photochemistry and Photobiology A. Chemistry" ISSN 1010-6030. 206:2-3 (Ago. 2009) 220-226.
Abstract(s)Fluorescence properties of the antitumoral methyl 3-(benzo[b]thien-2-yl)-benzothieno[3,2-b]pyrrole-2-carboxylate (BTP) were studied in solution and in lipid bilayers of dipalmitoyl phosphatidylcholine (DPPC), dioleoyl phosphatidylethanolamine (DOPE) and egg yolk phosphatidylcholine (Egg-PC). BTP presents good fluorescence quantum yields in all solvents studied (0.20 ≤ ΦF ≤ 0.32) and a bathochromic shift in polar solvents. The results indicate an ICT character of the excited state, with an estimated dipole moment of μe = 7.38 D. Fluorescence (steady-state) anisotropy measurements of BTP incorporated in lipid membranes of DPPC, DOPE and Egg-PC indicate that this compound is deeply located in the lipid bilayer, feeling the difference between the rigid gel phase and fluid phases. BTP inhibits the growth of three human tumour cell lines, MCF-7 (breast adenocarcinoma), SF-268 (glioma) and NCI-H460 (non-small cell lung cancer), being significantly more potent against the NCI-H460 tumour cells.
TypeArticle
URIhttp://hdl.handle.net/1822/11762
DOI10.1016/j.jphotochem.2009.07.007
ISSN1010-6030
Publisher versionwww.sciencedirect.com
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CDF - FAMO - Artigos/Papers (with refereeing)

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