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|Title: ||A dynamical model for the fermentative production of fructooligosaccharides|
|Authors: ||Rocha, Orlando|
Rodrigues, L. R.
Teixeira, J. A.
Ferreira, E. C.
|Issue date: ||2009|
|Citation: ||INTERNATIONAL SYMPOSIUM ON PROCESS SYSTEMS ENGINEERING, 10, São Salvador, Brasil, 2009 – “International Symposium on Process Systems Engineering: PSE2009”. [S.l.]: Elsevier. 2009. ISBN 978-0444534729|
|Series/Report no.: ||2009;|
|Abstract: ||In this paper a detailed mathematical model is presented for the fermentative production
of fructo-oligosaccharides with Aspergillus sp. The model accounts for hydrolysis and
transfructolization reactions, as well as biomass formation and it contains 27 parameters
that were determined from experimental data using a System Biology toolbox with the
Simulated Annealing method for curve fitting. Several additional experiments were
performed in bioreactors where the time variation of 7 state variables (Sucrose, Glucose,
Fructose, 1-Kestose, Nystose, 1-fructosyl nystose and Biomass) was measured.
Experimental data were compared with results from simulations using the estimated
parameters and it was verified that the model can predict the FOS production profile.
The good agreement between simulated and experimental data was verified by
calculating the relative percentage deviation modulus, which was lower than 10% for all
cases except one. The derived and validated model can be used for process
optimization, for example for indicating which fed-batch strategy could be used to
improve the production of FOS while minimizing glucose concentration.|
|Appears in Collections:||CEB - Artigos em Livros de Atas / Papers in Proceedings|
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